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Naloxone is a medication that can reverse an overdose that is caused by an opioid drug (i.e. prescription pain medication or heroin). When administered during an overdose, naloxone blocks the effects of opioids on the brain and restores breathing within two to eight minutes. Naloxone has been used safely by medical professionals for more than 40 years and has only one function: to reverse the effects of opioids on the brain and respiratory system in order to prevent death.

Naloxone Frequently Asked Questions 

What is Act 139?

Senate Bill 1164 was signed into law in late Sept. as Act 139 of 2014. This legislation allows first responders including law enforcement, fire fighters, EMS or other organizations the ability to administer a medication known as naloxone, a life-saving opioid reversal medication, to individuals experiencing an opioid overdoes. The law also allows individuals such as friends or family members that may be in a position to assist a person at risk of experiencing an opioid related overdose to obtain a prescription for naloxone. Additionally, Act 139 provides immunity from prosecution for those responding to and reporting overdoses.

How do I get naloxone?

Family, friends and individuals at risk of opioid overdose can access this medication from a pharmacy by obtaining a prescription from their family doctor or by using the standing order (a prescription written for the general public, rather than specifically for an individual) issued by Pennsylvania's Acting Secretary of Health and Physician GeneralThe standing order is kept on file at many pharmacies, or may be downloaded here.  Naloxone prescriptions can be filled at most pharmacies.  Although the medication may not be available for same day pick up, it can often be ordered and available within a day or two. 

Family members, friends and individuals at risk of opioid overdose can also access this medication for free from some local community-based organizations (CBOs).  The standing order may be used by CBOs that are in a position to assist a person at risk of experiencing an opioid-related overdose, to obtain Naloxone and provide it to individuals at risk of experiencing an opioid-related overdose, their family members and friends, or other persons in a position to assist a person at risk of experiencing an opioid-related overdose.  CBOs may provide Naloxone in person or via mail.

If you do not have health insurance or if cost is a barrier, you might want to get free naloxone by mail. Through a partnership with the Pennsylvania Commission on Crime and Delinquency and NEXT Distro, anyone can get naloxone mailed to their home for free. Get Free Naloxone Mailed to You.

How do first responders get naloxone?

Launched in 2017, the Pennsylvania Commission on Crime and Delinquency Naloxone for First Responders Program (NFRP) provides and distributes free kits containing two 4mg intranasal naloxone doses to organizations and individuals who may encounter someone experiencing an overdose ("first responders"). A wide range of community-based organizations, agencies, and other entities are eligible to receive a supply of naloxone at no cost through Centralized Coordinating Entities (CCEs) across the state. Learn more.

What types of naloxone are available?

Two of the most common ways that naloxone is administered are intranasal (nasal spray) and the auto-injector. Please note, not all pharmacies stock both forms and insurance coverage may vary depending on the type of medication being purchased and each individual insurance plan. Check your insurance prescription formulary or call your benefits manager to determine if the medication is covered by your particular plan or if your purchase of the medication will be an out-of-pocket cost.  

Naloxone Forms:

  • Intra-nasal Naloxone
    Prepackaged intra-nasal naloxone products require little to no assembly and are sprayed into one nostril while a person lays on their back. For people who have no formal training, nasal spray naloxone may be easier to use.
  • Intra-muscular Naloxone
    • Pre-filled Syringe
      Pre-filled injectable syringe naloxone products are injected with a needle into the outer thigh, similar to an Epi-pen. Syringe naloxone products may be easier for people who have experience administering medicine with a needle.
    • Non-pre-filled Syringe with Naloxone Vial
      Intra-muscular naloxone can also consist of a non-pre-filled syringe with a vial that contains liquid naloxone. The syringe is used to draw the liquid naloxone into the syringe before administration. Once filled with the correct amount of liquid naloxone, the syringe needle is inserted and administered into the muscle of the upper arm or thigh. Non-pre-filled needle-syringe naloxone products may be easier for people who have experience using a syringe to draw liquid medicine from a vial and administering medicine with a needle.
View the naloxone product fact sheet for more information and safety instructions. 

How do I administer naloxone?

In addition to talking to your healthcare provider or the pharmacist about how to use naloxone, individuals giving this medication to someone should take the online training ahead of time.  Training is available at the Department of Health’s approved training on TRAIN PA. This easy to understand training will cover the origins of the opioid crisis, explain how to recognize the signs and symptoms of an opioid overdose, what to do in the event of an overdose, and instruct on how to give naloxone.  While it is not necessary to obtain a training certificate in order to purchase naloxone, learning these important details will help you respond properly in the event of an overdose and also meet the immunity requirements of PA Act 139.

Could I get in trouble for giving someone naloxone?

Good Samaritan:  Through the 'Good Samaritan' provision of Act 139, friends, loved ones and bystanders are encouraged to call 911 for emergency medical services in the event an overdose is witnessed and to stay with the individual until help arrives.  The provision offers certain criminal and civil protections to the caller so that they cannot get in trouble for being present, witnessing and reporting an overdose.

Administering Naloxone:  Physicians are permitted to write third party prescriptions for naloxone and you are immune from liability for giving naloxone if you believed the person was suffering from an opioid overdose (heroin or prescription pain medication) and you called for medical help/911 after giving the medication.

Does insurance cover naloxone?

Insurance companies vary in how they cover naloxone and other drugs used to treat an opioid overdose. Prior to having a naloxone prescription filled with a pharmacy, consumers are encouraged to check with their insurance carriers to find out whether naloxone is a covered benefit under their policy, and, if so, what form of naloxone is covered, and any cost-sharing amounts that may apply under their policy. 

Will fee-for-service and the managed care organizations pay for naloxone dispensed under the standing order for medical assistance recipients?


Will medical assistance require a prescription in order for the pharmacist to fill the naloxone for a medical assistance recipient?

Yes, per 55 Pa Code, Chapter 1121 – Pharmaceutical Services - §1121.52, pharmacists can treat the standing order as a verbal order for Medical Assistance recipients.

Can a person other than the eligible medical assistance recipient (friend/family member) obtain the naloxone at the pharmacy on the recipient's behalf? Will the medical assistance program make payment?

PA Medical Assistance will make payment for naloxone for the eligible medical assistance recipient.

Is prior authorization required by medical assistance for naloxone products?

Naloxone injection and Narcan Nasal Spray are covered by Medical Assistance without the need for prior authorization.

Where can a pharmacy access medical assistance billing procedures for naloxone and the nasal actuator?

The Fee-for-Service Program will post information related to billing for naloxone on the DHS Pharmacy Services website.  Pharmacies will need to contact each MCO individually to obtain information about their billing procedures.

Will copays apply for the naloxone products and nasal actuator?

No, the medical assistance copay will not apply.  

Is there a limit to the number of times that a medical assistance recipient can get naloxone?

No, there is no limit to the number of fills that can be obtained.

How can someone with an addiction to prescription pain medicines, heroin or other drugs get help?

Treatment for drug abuse and addiction is available!  You can find out more by calling the County Drug and Alcohol Office where you live.  For more information or to get the contact information for your local office visit the Get Help Now website or call 717-783-8200.

While it may be uncomfortable to talk to someone about their substance abuse problem, research shows that it is more likely for an individual to seek help for their problem within 30 days following an overdose if someone talks to them right after the overdose event about going to treatment. 

Are there any other standing orders in Pennsylvania?

Yes. There have been three well-publicized standing orders that we are aware of to date that impact Pennsylvania which include: 1) CVS who has developed one for their pharmacies nationwide; 2) Montgomery County; and 3) Allegheny County.