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Naloxone is a medication that can reverse an overdose that is caused by an opioid drug (i.e., prescription pain medication, heroin, or illicit fentanyl). When administered during an overdose, naloxone blocks the effects of opioids on the brain and restores breathing within 2 to 3 minutes. Naloxone has been used safely by medical professionals for more than 40 years and has only one function: to reverse the effects of opioids on the brain and respiratory system in order to prevent death. As of August 1, 2023, the Food and Drug Administration (FDA) has approved three naloxone products for over the counter (OTC) use. As of September 2023, naloxone is now available over the counter. Products approved by the FDA for sale over the counter include:

  • Narcan™ 4mg naloxone nasal spray, manufactured by Emergent BioSolutions
  • A generic naloxone 4mg nasal spray, manufactured by Padagis
  • RiVive™ 3mg naloxone nasal spray, manufactured by Harm Reduction Therapeutics
    • ​Availability of these products may vary by store.​​

Naloxone Frequently Asked Questions​


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