Pennsylvania Department of Health > My Health > A-Z Health Topics > Q-T > Sexually Transmitted Diseases Program > Human Papillomavirus and Genital Warts Facts
WHAT IS HUMAN
Human papillomavirus (HPV) is one of the most common causes of sexually
transmitted infection (STI) in the world. More than 100 different types of HPV
exist, most of which are harmless. About 30 types are spread through sexual
contact. Some types of HPV cause genital warts single or multiple bumps that
appear in the genital areas of men and women including the vagina, cervix,
vulva (area outside of the vagina), penis, and rectum. Many people infected
with HPV have no symptoms.
There are high-risk and low-risk types of HPV. High-risk HPV
may cause abnormal Pap smear results, and could lead to cancers of the cervix,
vulva, vagina, anus, or penis. Low-risk HPV also may cause abnormal Pap results
or genital warts.
Health experts estimate there are more cases of genital HPV
infection than any other STI in the United States. According to the American
Social Health Association, approximately 5.5 million new cases of sexually
transmitted HPV infections are reported every year. At least 20 million people
in this country are already infected.
WHAT ARE GENITAL WARTS?
Genital warts (sometimes called condylomata acuminata or
venereal warts) are the most easily recognized sign of genital HPV infection.
Many people, however, have a genital HPV infection without genital warts.
Genital warts are soft, moist, or flesh colored that appear
in the genital area within weeks or months after infection. They sometimes
appear in clusters that resemble cauliflower-like bumps, and are either raised
or flat, small or large. Genital warts can show up in women on the vulva and
cervix, and inside and surrounding the vagina and anus. In men, genital warts
can appear on the scrotum or penis. There are cases where genital warts have
been found on the thigh and groin.
CAN HPV CAUSE OTHER KINDS OF WARTS?
Some types of HPV cause common skin warts, such as those
found on the hands and soles of the feet. These types of HPV do not cause
HOW ARE GENITAL WARTS SPREAD?
Genital warts are very contagious and are spread during
oral, vaginal, or anal sex with an infected partner. They are transmitted by
skin-to-skin contact during vaginal, anal, or (rarely) oral sex with someone
who is infected. About two-thirds of people who have sexual contact with a
partner with genital warts will develop warts, usually within 3 months of
In women, the warts occur on the outside and inside of the
vagina, on the opening to the uterus (cervix), or around the anus.
In men, genital warts are less common. If present, they
usually are seen on the tip of the penis. They also may be found on the shaft
of the penis, on the scrotum, or around the anus.
Rarely, genital warts also can develop in your mouth or
throat if you have oral sex with an infected person.
Like many STIs, genital HPV infections often do not have
signs and symptoms that can be seen or felt. One study sponsored by the
National Institute of Allergy and Infectious Diseases (NIAID) reported that
almost half of women infected with HPV had no obvious symptoms. If you are
infected but have no symptoms, you can still spread HPV to your sexual partner
and/or develop complications from the virus.
HOW ARE HPV AND GENITAL WARTS DIAGNOSED?
Your health care provider usually diagnoses genital warts by
seeing them. If you are a woman with genital warts, you also should be examined
for possible HPV infection of the cervix.
Your provider may be able to identify some otherwise
invisible warts in your genital tissue by applying vinegar (acetic acid) to
areas of your body that might be infected. This solution causes infected areas
to whiten, which makes them more visible. In some cases, a health care provider
will take a small piece of tissue from the cervix and examine it under the
If you have an abnormal Pap smear result, it may indicate
the possible presence of cervical HPV infection. A laboratory worker will
examine cells scraped from your cervix under a microscope to see if they are
HOW ARE HPV AND GENITAL WARTS TREATED?
HPV has no known cure. There are treatments for genital
warts, though they often disappear even without treatment. There is no way to
predict whether the warts will grow or disappear. Therefore, if you suspect you
have genital warts, you should be examined and treated, if necessary.
Depending on factors such as the size and location of your
genital warts, your health care provider will offer you one of several ways to
podophyllin antimitotic solution
5 percent 5-fluorouracil cream
If you are pregnant, you should not use podophyllin or
podofilox because they are absorbed by your skin and may cause birth defects in
your baby. In addition, you should not use 5-fluorouracil cream if you are
If you have small warts, your health care provider can
remove them by one of three methods.
If you have large warts that have not responded to other
treatment, you may have to have surgery to remove them.
Some health care providers use the antiviral drug alpha
interferon, which they inject directly into the warts, to treat warts that have
returned after removal by traditional means. The drug is expensive, however,
and does not reduce the rate that the genital warts return.
Although treatments can get rid of the warts, none get rid
of the virus. Because the virus is still present in your body, warts often come
back after treatment.
HOW CAN HPV INFECTION BE PREVENTED?
The only way you can prevent getting an HPV infection is to
avoid direct contact with the virus, which is transmitted by skin-to-skin
contact. If you or your sexual partner has warts that are visible in the
genital area, you should avoid any sexual contact until the warts are treated.
Research studies have not confirmed that male latex condoms
prevent transmission of HPV, but studies do suggest that using condoms may
reduce your risk of developing diseases linked to HPV, such as genital warts
and cervical cancer. Unfortunately, many people who don’t have symptoms don’t
know that they can spread the virus to an uninfected partner.
POSSIBLE COMPLICATIONS OF HPV AND GENITAL WARTS
Some types of HPV can cause cervical cancer. Other types are
associated with vulvar cancer, anal cancer, and cancer of the penis (a rare
Most HPV infections do not progress to cervical cancer. If
you are a woman with abnormal cervical cells, a Pap test will detect them. If
you have abnormal cervical cells, it is particularly important for you to have
regular pelvic exams and Pap tests so you can be treated early, if necessary.
Pregnancy and Childbirth
Genital warts may cause a number of problems during
pregnancy. Sometimes they get larger during pregnancy, making it difficult to
urinate. If the warts are in the vagina, they can make the vagina less elastic
and cause obstruction during delivery.
Rarely, infants born to women with genital warts develop
warts in their throats (laryngeal papillomatosis). Although uncommon, it is a
potentially life-threatening condition for the child, requiring frequent laser
surgery to prevent obstruction of the breathing passages. Research on the use
of interferon therapy with laser surgery indicates that this drug may show
promise in slowing the course of the disease.
Scientists are doing research on two types of HPV vaccines.
One type would be used to prevent infection or disease (warts or pre-cancerous
tissue changes). The other type would be used to treat cervical cancers.
Researchers are testing both types of vaccines in people.
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